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Summit rises as lung cancer drug trial results show 15% higher survival rates than rival's

Summit Therapeutics shares rose up to 7% before bell ringing?after its ivonescimab treatment with China-based Akeso helped advanced lung cancer patients?live 15% longer than BeOne Medicines Tevimbra immunotherapy.

Late-stage trial results revealed that in a head to head study conducted in China, patients with advanced non-small-cell lung cancer squamous who were treated with ivonescimab, chemotherapy and Tevimbra lived on average 27.9 months compared to 23.7 months when they received Tevimbra, chemotherapy and Tevimbra.

Tyler Van Buren, TD Cowen's analyst, said: "This is a significant advancement in a situation?where other treatments have never found success."

Ivonescimab belongs to a class of newer medicines called bispecific antibodies. These have two targets. It blocks the protein PD-1, which helps cancer to avoid immune attacks and a second called?VEGF, which can promote tumor growth.

Summit Therapeutics holds the rights to the drug in the U.S.A., Canada Europe and Japan, through a $5 billion deal, while Akeso has the rights to China and the rest.

This study included 532 patients newly diagnosed with advanced non-small cell lung carcinoma in stage 3 or 4. The study compared ivonescimab and Tevimbra in the first-line treatment. All patients received chemotherapy.

The results of this study were presented in Chicago at the American Society of Clinical Oncology meeting.

Faisal Khurshid, an analyst at Jefferies, said that since the study had only been conducted 'in China,' it was still necessary to see if the same benefits were seen in trials around the world, particularly in the United States and Europe.

Julie Gralow is ASCO's Chief Medical Officer. She said that the new China-only data will not be used for U.S. approval. However, a separate global?late stage trial comparing ivonescimab with Merck's Keytruda should produce interim 'data' later this year.

Summit's shares rose 2.7% in Monday premarket trading to $18.01. Stock has been mostly flat this year. (Reporting and editing by Pooja Deai in Bengaluru, Christy Santhosh from Bengaluru)

(source: Reuters)