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Patrik Laine, Habs shoot for home-and-home sweep of Wings
Patrik Laine has actually been mighty productive, particularly on the power play, given that signing up with the Montreal Canadiens. He likewise stays especially effective versus the Detroit Red Wings throughout his career. After notching the game-winner at Detroit on Friday, Laine seeks to stay hot and help the host Canadiens sweep a back-to-back set versus the Red Wings on Saturday night. Laine, obtained by the Canadiens from the Columbus Blue Jackets in an August trade, missed Montreal's first 24 video games due to a knee injury. However, in eight games since making his Canadiens debut Dec. 3, he has totaled 7 goals-- remarkably, all on the power play. In truth, all of Montreal's power-play goals, in 25 opportunities given that Dec. 3, have been scored by Laine. His newest objective featured 7:58 left in regulation on Friday and offered the Canadiens a 4-3 lead. That margin stood, and Montreal has actually now published back-to-back triumphes following a 1-3-0 stretch. Him scoring objectives and assisting the group win on the power play is big, Montreal coach Martin St. Louis stated. It's a big part of when your special groups are running good. The Canadiens, who are in the middle of a 6-3-1 stretch in your home, made simply their fourth road win of the season, tied for 2nd least in the NHL. A really good one for us, and turn the page for (Saturday), Montreal defenseman Kaiden Guhle said. Laine, who has actually scored four goals in the past two contests, has 11 goals (2. on the power play) plus 8 assists in 21 career video games vs. the Reds Wings. Detroit gets in the back end of the home-and-home amid a 3-5-2 stretch. On Friday, goals from Patrick Kane, Joe Veleno and Tyler Motte had the Red. Wings up 3-2 early in the 3rd duration. However, they might not hold that. benefit in their bid for a third consecutive success. Perhaps fortunately for Detroit is that it does not have long to wait for a. chance to avenge the defeat. That's the very best part about it, said Red Wings star Dylan Larkin, who was. blanked Friday after totaling six points, all assists, in the previous five. games. We've just got to capitalize on our opportunities and play with a little bit more. intensity. Reduce our errors. Kane has two objectives with 2 helps in the past three games after going nine. directly without a point. On the other hand, teammate Michael Rasmussen had two. assists Friday, and he has 4 points in the previous three video games. Detroit goalie Cam Talbot was credited with 29 saves on Friday, and he has actually a. 3.89 goals-against average during his current 0-3-1 stretch. Alex Lyon could get the start in the back-to-back situation after he enabled. four objectives on 19 shots dealt with throughout a 6-4 loss to the Philadelphia Flyers on. Wednesday in his return from missing nine games with a lower-body injury. Montreal's Sam Montembeault (2.93 GAA) made 25 conserves to win his second. straight begin on Friday, and it's possible he could be in net once again on. Saturday. Canadiens backup Cayden Primeau has actually allowed 11 objectives on 60 shot. attempts in his past 3 outings-- two of which were starts. Teammate Jake Evans, who scored a short-handed objective in his 300th profession NHL. video game on Friday, and has four points in the past four contests. -- Field Level Media
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France adds first atomic power plant in 25 years to grid
France connected the Flamanville 3 atomic power plant to its grid on Saturday morning, staterun operator EDF stated, in the first addition to the country's nuclear power network in 25 years. The reactor, which began running in September ahead of the grid connection, is going online 12 years behind originally prepared and at an expense of around 13 billion euros - four times the original budget. EDF groups have attained the very first connection of the Flamanville EPR to the nationwide grid at 11:48 am (1048 GMT). The reactor is now creating electrical energy, EDF stated in a statement. The Flamanville 3 European Pressurised Reactor is France's. biggest at 1.6 gigawatts (GW) and among the world's greatest,. together with China's 1.75 GW Taishan reactor, which is based on a. similar style, and Finland's Olkiluoto. It is the very first to be connected to the grid because Civaux 2. in 1999 however is being brought into service at a time of sluggish. consumption, with France exporting a record amount of. electrical power this year. EDF is planning to construct another 6 new reactors to fulfil. a 2022 pledge made by President Emmanuel Macron as part of the. nation's energy shift plans, although concerns stay. around the funding and timeline of the brand-new jobs.
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Islamist militants in northwest Pakistan kill 16 security personnel, law enforcement officers states
Sixteen security personnel were killed in northwest Pakistan in an attack by Islamist militants early on Saturday, a senior authorities official in the South Waziristan region stated, as Islamist fighters step up their attacks on the security forces. Another eight personnel were injured in the attack on a. security forces post, which took place at 2 a.m. (2100 GMT on. Friday), authorities deputy superintendent Hidayat Ullah informed. Reuters. A search operation is under way in the area, he added,. stating the assailants had actually utilized light and heavy weapons. Tehreek-e-Taliban Pakistan (TTP), likewise referred to as the Pakistan. Taliban, claimed obligation for the attack, giving a higher. figure for the number of security workers eliminated. At least 35 security personnel were killed and 15 hurt. in the attack, the group stated in a WhatsApp channel broadcast. It did not say whether any of its fighters had actually been killed. The TTP has performed more regular attacks in current. months, primarily targeting members of the security forces. An umbrella group of different Sunni Islamist militant groups,. it has actually long been combating in a quote to topple the federal government. and change it with a stringent Islamic-led system of governance. It is separate from the Afghan Taliban movement, however pledges. commitment to the Islamist group that now rules Afghanistan after. the withdrawal of U.S.-led worldwide forces in 2021.
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Petrobras Steps Closer to Developing Hydrogen Plant Powered by Renewables
Petrobras has signed a protocol of intent Companhia Siderúrgica Nacional (CSN) and CSN Inova Soluções, marking a first step towards structuring a business partnership aimed at setting up a low-carbon hydrogen plant on a commercial scale in Brazilian state of Paraná.Low-carbon hydrogen can be used in industrial processes or as fuel and will be obtained through the electrolysis of water from renewable sources of electricity. The initiative aims to support the decarbonization efforts of CSN and Petrobras' operations and products.Petrobras did not specify which renewable energy sources would be used to power the production of hydrogen.The signing of this Protocol of Intent is in line with the Petrobras’ Strategic Plan 2050 and Business Plan 2025-2029, which aim to prepare Petrobras to lead the fair energy transition, reducing its emissions and expanding the supply of more sustainable products.
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Thai ceremony for the dead brings good karma and psychological closure
When two month old Bibeam passed away in November 2023, the temples in her district would not cremate her, considering her too young for such an event. Rather she was buried without any religious rites in a. cemetery in Rayong, about two hours southeast of the Thai. capital Bangkok and one hour from her household's home. It was just this year that Bibeam was given the Buddhist. cremation her parents had wanted when she was consisted of in a rare. Lang Pa Cha cemetery cleaning ceremony, a ritual that. originated during China's Tune dynasty and was brought to. Thailand by Chinese immigrants. I am extremely pleased and delighted that my baby can have her. funeral rite like others, her mother, 26-year-old Paikaew. Thaijaroen, informed Reuters. Lang Pa Cha ceremonies occur every year at cemeteries. throughout Thailand's 77 provinces and are organised by a small. group of non-profit organisations. The ritual involves exhuming remains and performing Buddhist. and Taoist rites in an event that is now special to the. Southeast Asian country, stated Sayomphu Kiatsayomphu, president. of Thailand's Cemeteries Cleansing Network. Cremation is extensively practised in Thailand, but people who. pass away without being officially identified, perhaps because they. moved a lot of were a migrant worker, are normally buried. Bibeam was included in the ceremony because when the. volunteers exhumed her grave, which was in the very same area as. those who were unclaimed, her body was found to have actually been. uncommonly well protected. The ultimate objective is to guarantee the ascension of these. unclaimed souls to paradise, Kiatsayomphu stated. When exhumed, the remains are cleaned by Buddhist volunteers. before a medium identifies their gender. For some of the volunteers the event assists in benefit. making - a Buddhist principle where performing kindness. adds to that individual's own joy and wellness. I first started Lang Pa Cha around 20 years back as a. volunteer, stated Tonploy Boonporn, a 63-year-old masseur. After. that, I found real spiritual fulfilment in this ceremony, so I. kept going. As the day of cremation draws near, the volunteers utilize. tooth brushes and holy water to carefully wash the mud from the. remains, before decorating them with gold leaf. The embellished remains are then set up in two different. pyres - one for males and one for women. The cemetery in Rayong, where Bibeam was cremated, had not. been cleansed for almost twenty years and included about 1,000. unclaimed bodies, according to Pakkhapoom Boonchothirun, an. executive member of the Sawang Pornkuson Foundation that runs. the graveyard and arranged the ceremony. The Lang Pa Cha happened between March and May. On the day of the cremation, Bibeam's body was put on top. of the funeral pyre, symbolically leading the souls of the. left on their journey to heaven. Seeing her maintained body put on the top of a female. funeral pyre makes me feel more complete, Paikaew said.
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Codelco copper output misses November target, document programs
Chile's staterun copper giant Codelco produced 125,500 metric lots of the metal in November, up 18% yearonyear, however still fell back its target for the month, an internal file acquired revealed Friday. The miner's output was 3% lower than anticipated, according to the file titled Preliminary Business Outcomes and dated in December. The only departments to satisfy their target were the enormous El Teniente and the smaller Radomiro Tomic. Codelco did not instantly respond to an ask for comment. The copper giant, which is the world's greatest producer of the red metal, has been intending to quicken production to meet its 2024 target after levels in the last 2 years hit a. quarter-century low. After November's efficiency, Codelco will still require to. produce more than 161,000 lots of copper in December to reach. the low-end of its target, which the business previously this year. put in between 1.325 million to 1.352 million tons. Senior company sources previously informed Reuters that. Codelco anticipates to end the year at 1.331 million tons, which. would be 0.5% above in 2015's output. November production was injured by delays at the Rajo Inca. job at the Salvador mine, according to the document. It also. revealed lower recovery and processing at the Andina, Chuquicamata. and Gabriela Mistral systems and lower ore grades at Ministro. Hales. Smelting and cathode production were likewise below. Codelco's target in November, according to the document.
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Nippon Steel declares excessive White Home impact on doomed offer review-letter
Nippon Steel declares the White Home had impermissible undue impact over a nationwide security review of its $14.9 billion bid for U.S. Steel and threatened legal action if the deal is blocked. The allegation was made in a Dec. 17 letter, signed by counsel for Nippon Steel and U.S. Steel and seen , to the Committee on Foreign Investment in the United States ( CFIUS). CFIUS, which reviews foreign acquisitions for nationwide security dangers, has a Monday due date to approve the deal, extend the evaluation, or suggest that President Joe Biden scuttle it. However, an expected government shutdown would stop briefly the clock, CFIUS attorneys said. Last weekend, CFIUS set the phase for Biden, who has long opposed the tie-up, to block it in a 29-page letter by raising supposedly unsettled nationwide security dangers, Reuters specifically reported. In its response, Nippon Steel and U.S. Steel rebut CFIUS's. nationwide security arguments and allege that Biden incorrectly. influenced the evaluation's result before CFIUS could reach its. conclusions. Specifically, their Dec. 17 letter claims Biden might have. weighed in on the offer to please United Steelworkers (USW). President David McCall, who opposes the tie-up, and backed. Biden for President soon after he revealed his opposition to. the merger. Biden has opposed the offer due to the fact that he thinks that U.S. Steel ought to be American-owned and operated. We are gravely worried that the December 14 Letter. reflects impermissible influence in the CFIUS procedure from the. White House, at the request of 3rd parties who oppose the. transaction and seek to weaken the Celebrations, particularly,. Cleveland-Cliffs ..., led by CEO Lourenco Goncalves, and Mr. McCall, Nippon and U.S. Steel's most current action to CFIUS checks out. Cleveland-Cliffs was a suitor for U.S. Steel and likewise. opposes the handle Nippon. White House representative Saloni Sharma said the accusation. is not real. She did not specifically address if Biden would. block the deal, adding, The President has actually been clear that he. will continue to see what the CFIUS process yields. We anticipate settling the deal and. remain devoted to working with all relevant parties to do so,. U.S. Steel said in a statement. Nippon Steel and Cleveland Cliffs CEO Lourenco Goncalves. decreased to comment. TOP-LEVEL OPPOSITION The proposed tie-up has faced top-level opposition within. the United States considering that it was revealed a year ago, with both. Biden and his inbound follower Donald Trump taking objective at it. as they sought to woo union citizens in the swing state of. Pennsylvania, where U.S. Steel is headquartered. Trump has also. asserted the iconic American business must remain. American-owned. The merger appeared fast-tracked to be obstructed after the. business got an Aug. 31 letter from CFIUS, seen by. Reuters, arguing the deal might injure the supply of steel required. for important transportation, construction and agriculture. tasks. But Nippon Steel countered that its investments, made by a. business from an allied nation, would in truth support U.S. Steel's output and won a 90-day evaluation extension. That extension. offered CFIUS up until after the November election to make a. decision, sustaining hope among advocates that a calmer political. environment could assist the offer's approval. PERSONAL ASSURANCES In making the case that President Biden was doing a favor to. McCall, the letter cited a February USW news release in which. the union leader specified, Today we received personal guarantees. that President Joe Biden has our backs, McCall said. He's. always been a pal to the American worker and our union, and. we're grateful he's taking an interest in this matter. The White House rejected the allegation Biden's opposition is. at the request of McCall and referred Reuters to his March. statement against the offer. McCall stated in a declaration that. Nippon's efforts to distribute unfounded reports and dangers of. legal action are regrettable, but eventually, they disappear. than a diversion from the dangers the company's acquisition of. U.S. Steel positions.. If Biden obstructs the offer, the Celebrations would right away submit. a petition in the U.S. Court of Appeals for the DC Circuit. challenging the decision as an offense of due procedure and the. authority of the President, under CFIUS authorities, Nippon. Steel composes.
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United States prepares to blacklist company that purchased TSMC chip found in Huawei processor, source states
The Biden administration prepares to blacklist a Chinese company whose TSMCmade chip was unlawfully integrated into a Huawei artificialintelligence processor, according to a person knowledgeable about the matter. The Chinese company, Sophgo, drew attention after a chip discovered on Huawei's Ascend 910B multi-chip system matched one it ordered from Taiwan Semiconductor Production Business . Sophgo is the most recent Chinese company slated to be penalized by the U.S. for helping Huawei. This month, the Commerce Department included other companies considered as part of Huawei's shadow network to the U.S. Commerce Department's restricted trade list. Sophgo, an affiliate of bitcoin mining devices provider Bitmain, is in the procedure of being put on the list, referred to as the Entity List, the source said. Companies are added to the list for activities contrary to U.S. national security and foreign-policy interests. Exporters are then disallowed from delivering goods and innovation to them without a license, which is most likely to be rejected. China's Huawei, a telecommunications equipment maker and technology corporation, was placed on the list in 2019. Given that 2020, it has actually been an infraction to deliver even foreign-made chips to the company without a license. A U.S. Commerce Department spokesperson declined to comment. Sophgo did not right away react to ask for comment. In an October statement, the company said it has never ever been taken part in any direct or indirect organization relationship with Huawei. Sophgo is a provider to city governments and state-owned firms such as China Telecom, according to tenders reviewed by Reuters. Over the past two years, Sophgo and Bitmain AI chips have been bought by Chinese state-run universities constructing AI tools and police headquarters seeking to upgrade their monitoring capabilities, according to the tender review. RESEARCH FIRM FOUND CHIP Tech research study firm TechInsights took apart the Huawei 910B, discovered the TSMC chip and informed the chipmaker, which alerted the U.S. Commerce Department, as Reuters reported in October. After figuring out the chip matched Sophgo's style, TSMC suspended shipments to the company, sources have said. TSMC, the world's biggest contract chipmaker, stated in October it has actually not supplied Huawei because 2020. A Taiwan authorities said that month that TSMC informed Taiwan and U.S. authorities and started a comprehensive investigation. A TSMC representative decreased comment on Friday about what the investigation had actually shown up. Beginning on Nov. 11, the U.S. purchased TSMC to stop deliveries to China of seven-nanometer or advanced chips that could be utilized in AI applications, as Reuters exclusively reported. Huawei said in October it has not produced any chips via TSMC considering that the U.S. imposed brand-new export guidelines on the business in 2020. It did not instantly react to a request for discuss Friday. When hobbled by the U.S. constraints, Huawei has because diversified and reappeared at the center of China's AI-chip aspirations. The business's Ascend 910B, released in 2022, is deemed the most sophisticated AI chip offered from a Chinese company. Huawei plans to begin mass producing its most recent chip, the Ascend 910C, meant to measure up to U.S. AI chipmaker Nvidia in early 2025, as Reuters reported last month. Sophgo was co-founded by Micree Zhan, who also co-founded Bitmain, according to a corporate registration database. Zhan still indirectly owns 23% of Xiamen Sophgo Technologies Ltd, and five of its subsidiaries by means of an investment automobile, Beihaishan Beside Investment Partnership, which he owns in full, according to Wirescreen, a business-intelligence platform and business records reviewed . Sophgo interacted with the U.S. Federal Communications Commission in 2023 utilizing a Bitmain e-mail address. Bitmain stated on social networks on Oct. 28 that it is not involved in or otherwise associated to the supply chain examination. Bitmain's website says it is the world's leading manufacturer of digital currency mining servers through its brand name Antminer, and that it has clients in over 100 nations.
Weight-loss drug developers line up to tap market worth $150 billion
Novo Nordisk's Wegovy and Eli Lilly's Zepbound are up until now the leaders in the weightloss drug market, which is estimated to be worth about $ 150 billion by the early 2030s.
There are also a number of other drug developers intending to join the bandwagon. The following is a list of publicly noted business targeting the next huge blockbuster chance:
NOVO NORDISK
Novo's closely-watched weight problems drug candidate CagriSema assisted overweight patients cut their weight by 22.7% in a. late-stage trial, but that was below its own expectations of up. to 25% reduction.
The data compares to weight-loss of about 15% after 68 weeks. in a trial for Wegovy.
CagriSema is a weekly injection, which integrates semaglutide,. the active component in Wegovy and simulates the gut hormonal agent. GLP-1, and a different molecule called cagrilintide that simulates. the pancreatic hormone amylin.
The two hormones integrated suppress hunger and help control. clients' blood glucose.
Novo is also establishing a weight-loss pill, amycretin, which. helped obese participants lose 13.1% of their weight after 12. weeks of treatment in an early-stage study.
The company stated in September it plans to decide on more. studies for amycretin after data from an early study on a. subcutaneous variation of the drug, which is anticipated next year.
It is set to purchase 3 of contract drug producer. Catalent's fill-finish sites in Italy, Belgium and the U.S. to. help boost Wegovy's production.
Novo Holdings, the managing investor of Novo Nordisk,. completed its acquisition of Catalent on Dec. 18.
ELI LILLY
Eli Lilly's weight-loss therapy, Zepbound, got the green. light from the U.S. and UK regulators last year, leading the way. for an effective new competitor to Novo's Wegovy.
Earlier in December, Lilly said clients taking Zepbound. lost 47% more weight than those who were provided Wegovy in the. first large, head-to-head trial of the highly sought-after rival. medications.
In the 751-person trial sponsored by Lilly, Zepbound assisted. clients lose an average of 20.2% of their weight after 72 weeks. compared to 13.7% for the group treated with Wegovy.
In 2023, Lilly had actually stated a mid-stage trial of its. next-generation weight problems drug candidate, a once-weekly injection. of retatrutide, caused weight-loss of as much as 24.2% after 48. weeks.
Lilly is presently testing retatrutide in late-stage trials.
It is testing another speculative weight problems pill,. orforglipron, in a late-stage trial and anticipates to reveal data. from the research study in April 2025.
The greatest dosage of orforglipron caused 14.7% weight loss. after 36 weeks in obese patients, information from a mid-stage trial. had actually revealed.
PFIZER
In July, Pfizer stated it planned to get in clinical. trials later on this year for a reworked, once-a-day version of its. weight-loss tablet, danuglipron.
The drugmaker said in 2015 it was stopping further trials. of a twice-daily version of danuglipron.
ROCHE AND CARMOT REHABS
Roche obtained CT-388 as part of its $2.7 billion. buyout of Carmot Rehabs. Carmot's once-a-week injection. belongs to the very same class as Eli Lilly's Mounjaro, or. Zepbound.
In July, the company announced that a 2nd drug candidate. from its purchase of Carmot yielded positive lead to an. early-stage trial.
Roche said its experimental pill, which might attract. clients averse to injections, was well endured with mostly. moderate or moderate intestinal side effects comparable to those. seen in other weight-loss drugs.
AMGEN
In November, Amgen's closely-watched speculative. obesity drug MariTide assisted overweight patients shed up to. 20% of their body weight in an year-long mid-stage trial.
Analysts said MariTide's weight-loss advantage was in line. with Wegovy and Zepbound, however had a little more adverse effects.
MERCK
In December, Merck signed a licensing offer worth up. to $2 billion for Chinese biotech Hansoh Pharma's. experimental oral drug to treat weight problems, becoming a late. contender in the race to provide a weight-loss tablet to change. weekly shots.
The drug, HS-10535, is a GLP-1 receptor agonist prospect. similar to Wegovy and Zepbound.
ASTRAZENECA
AstraZeneca's experimental weight-loss pill,. licensed a year ago from China's Eccogene for approximately $2 billion,. was discovered to be safe and tolerable in an early-stage trial in. November.
The drugmaker stated it has actually progressed the once-daily pill,. called AZD5004, into mid-stage trials.
ALTIMMUNE
Altimmune said in 2015 its drug candidate,. pemvidutide, helped in reducing weight by 15.6% on average and revealed. continued weight loss at the end of treatment in a mid-stage. trial.
Clients, nevertheless, likewise experienced queasiness and throwing up of. moderate and moderate intensity.
VIKING REHABS
Viking Rehabs stated in February its. experimental drug, VK2735, assisted clients attain approximately 14.7%. suggest weight loss after 13 weeks of treatment in a mid-stage. research study, which had actually registered 176 overweight adults with a minimum of. one weight-related comorbidity.
In November, the business stated the drug helped 9 patients,. who received the highest 100 milligram dosage, lose approximately. 8.2% of their body weight after 28 days in an early-stage trial.
ZEALAND PHARMA
Danish biotech Zealand Pharma said in June a high. dosage of its weight-loss drug candidate petrelintide helped. decrease weight by a typical 8.6% after 16 weekly dosages in an. early-stage research study.
The company said in August it is set to start talks with. other pharmaceutical business in the second half of this year. for potential collaborations to establish and advertise. petrelintide.
Zealand is presently evaluating petrelintide in overweight or. overweight individuals without type 2 diabetes in a mid-stage study.
STRUCTURE THERAPEUTICS
Structure Therapies said in June its. experimental oral weight problems drug helped reduce weight by 6.2% on. average at the end of 12 weeks in a mid-stage study.
(source: Reuters)