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Researchers discover key to preventing a common liver transplant complication

Researchers discover key to preventing a common liver transplant complication

A study on mice suggests that researchers may have discovered a way to increase the success rate of liver transplants by finding a solution to a complication known to cause failure in the new organ.

When the liver is removed from a donor, its blood supply is interrupted. The influx of blood that occurs when the blood supply is restored after transplantation causes inflammation in the liver. This is called ischemia-reperfusion damage.

Graft failure and dysfunction can result from the cascade of molecular and cellular events that follow.

Researchers discovered in previous experiments that a CEACAM1 protein helps protect the liver against injury during transplantation.

In their most recent study published in JCI Insights they discovered that CEACAM1 together with another protein called Human Antigen R(HuR) act as protective switches to prevent ischemia and reperfusion injury.

The researchers also discovered a way of boosting these switches in mice. This increased their protective effect, and reduced the harmful stress on the liver.

Researchers found that the same protective relationship existed between HuR, and CEACAM1 when they examined discarded livers from humans deemed unsuitable to be transplanted.

In a press release, study leader Kenneth Dery of UCLA's David Geffen School of Medicine said that the shortage of liver donors in the United States has resulted in high mortality rates among patients waiting for liver transplants.

This could help to address the national shortage of transplants and reduce mortality.

Air pollution may be damaging to children's eyesight

A new study suggests that air pollution can harm children's vision. Cleaner air, on the other hand, may protect their eyesight and improve it.

Researchers reported in PNAS that exposure to air pollution - specifically fine particulates (PM2.5) and nitrogen dioxide - is associated with the ability of children to see without glasses.

Genetics and lifestyle, including screen time, can play a significant role in determining whether a child has myopia or short-sightedness. This condition causes distant objects to appear blurry.

The research team found that environmental factors are also important. They used advanced machine-learning techniques to study the air pollution exposure of nearly 30,000 children aged between 6 and 18 years.

They found that after accounting for the other risk factors of myopia, lower levels nitrogen dioxide and fine particle in the air are independently associated with improved vision.

The study also showed that children in primary school and those with mild to moderate myopia benefited more from cleaner air compared to students who were highly myopic. This suggests that taking action early, before the problem becomes severe, can have a positive impact.

The study cannot prove that air pollution causes myopia.

In a press release, Professor Zongbo Schi from the University of Birmingham, UK, said that the study was among the first to identify air pollution as an important and modifiable factor in childhood myopia.

Researchers said that installing air purifiers around classrooms to reduce pollution and creating "clean-air areas" to reduce car traffic could improve eye health.

Shi added that "clean air is not just about respiratory health. It's also about visual health." Sign up for the newsletter to receive it in your mailbox. (Reporting and editing by Bill Berkrot; Nancy Lapid)

(source: Reuters)